Theoretical Design of Continuous Antibiotic Fermentation Units
نویسندگان
چکیده
منابع مشابه
Theoretical design of continuous antibiotic fermentation units.
A graphic method of predicting antibiotic yields in continuous flow reactors is presented and discussed using the novobiocin fermentation as a model process. Extension to other antibiotic fermentations and steroid bioconversions is emphasized. In the case of the novobiocin fermentation it was concluded that a combination of one growth stage and one or two antibiotic production stages would be t...
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The feasibility of producing antibiotics by single-stage continuous fermentation was explored by means of a specially designed pilot plant. Both the chloramphenicol and penicillin processes appeared adaptable to such an operation. At dilution rates of 1.0 and 0.5 volume changes per day respectively, yields of from & to 4 of the maxima obtained in batch operation were maintained in the steady-st...
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Continuous fermentation trials with Streptomyces niveus in a nine-stage fermentation system (7-liter reaction volume per stage) indicated that the cultures used gradually lost their ability to produce novobiocin when cultured over periods from 10 to 25 days. It was found that mycelial degeneration could be circumvented by operational means during continuous culture using the following technique...
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Controlling antibiotic-resistant (ART) bacteria in cheese fermentation is important for food safety and public health. A plant-maintained culture was found to be a potential source for ART bacterial contamination in cheese fermentation. Antibiotics had a detectable effect on the ART population from contamination in the finished product. The decrease in the prevalence of antibiotic resistance (A...
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Continuous ethanol fermentation from cheap sugar cane molasses was studied. Two strains of Saccharomyces cerevisiae were used, one of them flocculent, in order to evaluate the performance of fluidized tubular reactors, with and without support for yeast immobilisation (polyurethane foam and expanded clay argilate granules were tested). In this heterogeneous continuous system, with three phases,...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1961
ISSN: 0003-6919
DOI: 10.1128/aem.9.5.361-366.1961